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dc.contributor.authorKayaman-Apohan, Nilhan
dc.contributor.authorSuleymanoglu, MEDİHA
dc.contributor.authorErdem-Kuruca, Serap
dc.contributor.authorOKTAY, BURCU
dc.date.accessioned2021-03-05T15:31:46Z
dc.date.available2021-03-05T15:31:46Z
dc.identifier.citationOKTAY B., Kayaman-Apohan N., Suleymanoglu M., Erdem-Kuruca S., "Zwitterionic phosphorylcholine grafted chitosan nanofiber: Preparation, characterization and in-vitro cell adhesion behavior", MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.73, ss.569-578, 2017
dc.identifier.issn0928-4931
dc.identifier.othervv_1032021
dc.identifier.otherav_bc50ee7d-de32-414d-803e-4619b6dccc26
dc.identifier.urihttp://hdl.handle.net/20.500.12627/125158
dc.identifier.urihttps://doi.org/10.1016/j.msec.2016.12.082
dc.description.abstractIn this study, zwitterionic phosphorylcholine grafted electrospun chitosan fiber was accomplished in three steps: (1) Azide groups on the chitosan were regioselectively replaced with hydroxyl side group and then the product was electrospun. (2) Chitosan based macroinitiator was prepared using an azide-alkyne click reaction from azide-functionalized electrospun chitosan fiber. (3) Poly(2-methacryloyloxyethyl phosphorylcholine) (MPC) was grafted onto the electrospun chitosan fiber by atom transfer radical polymerization (ATRP) in order to enhance cellular viability and proliferation of 3T3, ECV arid Saos. The structure of surface modified thitosan was characterized by Fourier transform infrared spectrometer (FT-IR) and H-1 nuclear magnetic resonance (H-1 NMR). The surface morphology of the nanofibers was investigated by scanning electron microscope (SEM). In vitro cellular attachment and spreading experiments of 3T3, ECV304 and Saos were performed on electrospun chitosan fibers in the presence and the absence of MPC grafting. Poly(MPC) grafted electrospun fiber showed an excellent performance due to phosphorylcholine groups mimicicing the natural phospholipid. (C) 2016 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.subjectMühendislik ve Teknoloji
dc.subjectMalzeme Bilimi
dc.titleZwitterionic phosphorylcholine grafted chitosan nanofiber: Preparation, characterization and in-vitro cell adhesion behavior
dc.typeMakale
dc.relation.journalMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.contributor.departmentMarmara Üniversitesi , Fen - Edebiyat Fakültesi , Kimya Bölümü
dc.identifier.volume73
dc.identifier.startpage569
dc.identifier.endpage578
dc.contributor.firstauthorID104385


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