dc.contributor.author | Ozdemirler-Erata, Guel | |
dc.contributor.author | Kocak-Toker, Necla | |
dc.contributor.author | Kucukgergin, Canan | |
dc.contributor.author | Aydın, Ali Fuat | |
dc.contributor.author | Mehmetcik, Gueldal | |
dc.contributor.author | Uysal, Muejdat | |
dc.date.accessioned | 2021-03-05T15:09:51Z | |
dc.date.available | 2021-03-05T15:09:51Z | |
dc.identifier.citation | Kucukgergin C., Aydın A. F. , Ozdemirler-Erata G., Mehmetcik G., Kocak-Toker N., Uysal M., "Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet", BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.135, ss.264-274, 2010 | |
dc.identifier.issn | 0163-4984 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_ba8ea893-f76a-442a-847c-2565eca04ae6 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/124083 | |
dc.identifier.uri | https://doi.org/10.1007/s12011-009-8484-9 | |
dc.description.abstract | Hypercholesterolemia and lipid peroxidation play complementary roles in atherosclerosis. Artichoke (Cynara scolymus L., Asteraceae) leaf extract (ALE), rich in antioxidants, has cholesterol-reducing effect. We investigated the effect of ALE on serum and hepatic lipid levels and pro-oxidant-antioxidant balance in the liver and heart of hypercholesterolemic rats. Rats were fed on 4% (w/w) cholesterol and 1% cholic acid (w/w) supplemented diet for 1 month. ALE (1.5 g/kg/day) was given by gavage during the last 2 weeks. High cholesterol (HC) diet caused significant increases in serum and liver cholesterol and triglyceride levels. It increased malondialdehyde (MDA) and diene conjugate (DC) levels in both tissues. Hepatic vitamin E levels and hepatic and cardiac glutathione peroxidase (GSH-Px) activities decreased, but superoxide dismutase and glutathione transferase activities, glutathione, and vitamin C levels remained unchanged due to HC diet. Serum cholesterol and triglyceride levels and ratio of cholesterol to high-density lipoprotein (HDL)-cholesterol decreased in ALE plus HC-treated rats, but liver cholesterol and triglyceride levels remained unchanged. Significant decreases in hepatic and cardiac MDA and DC levels and increases in hepatic vitamin E and GSH-Px activities were observed in ALE-treated hypercholesterolemic rats. Our results indicate that ALE decreases serum lipids and hypercholesterolemia-induced pro-oxidant state in both tissues. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.title | Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet | |
dc.type | Makale | |
dc.relation.journal | BIOLOGICAL TRACE ELEMENT RESEARCH | |
dc.contributor.department | İstanbul Teknik Üniversitesi , İnşaat , Çevre Mühendisliği | |
dc.identifier.volume | 135 | |
dc.identifier.startpage | 264 | |
dc.identifier.endpage | 274 | |
dc.contributor.firstauthorID | 16911 | |