dc.contributor.author | Ceylan, Mehmet Emin | |
dc.contributor.author | Dasdemir, Selcuk | |
dc.contributor.author | Turkcan, Ayse Solmaz | |
dc.contributor.author | Bireller, Elif Sinem | |
dc.contributor.author | Cakmakoglu, Bedia | |
dc.contributor.author | Ermis, Aysegul | |
dc.contributor.author | Erkiran, Murat | |
dc.date.accessioned | 2021-03-05T15:06:24Z | |
dc.date.available | 2021-03-05T15:06:24Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Ermis A., Erkiran M., Dasdemir S., Turkcan A. S. , Ceylan M. E. , Bireller E. S. , Cakmakoglu B., "The Relationship Between Catechol-O-Methyltransferase Gene Val158Met (COMT) Polymorphism and Premorbid Cannabis Use in Turkish Male Patients with Schizophrenia", IN VIVO, cilt.29, ss.129-132, 2015 | |
dc.identifier.issn | 0258-851X | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_ba6c7533-79f5-429b-96b2-9005ad168a5d | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/123992 | |
dc.description.abstract | Background/Aim: One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage. Patients and Methods: The study group consisted of 80 male patients and genotyping of COMT enzyme Val158Met gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: It was found that the Val/Val genotype is significantly higher in patients with premorbid cannabis use (88.9%) compared to patients without pre-morbid cannabis use (68.4%). Also, the mean total positive and negative syndrome scale (PANSS) score seen in the Val/Val genotype group is significantly higher than the scores of the patients with the Met allele. Conclusion: The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia. | |
dc.language.iso | eng | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.title | The Relationship Between Catechol-O-Methyltransferase Gene Val158Met (COMT) Polymorphism and Premorbid Cannabis Use in Turkish Male Patients with Schizophrenia | |
dc.type | Makale | |
dc.relation.journal | IN VIVO | |
dc.contributor.department | Esenyurt State Hospital , , | |
dc.identifier.volume | 29 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 129 | |
dc.identifier.endpage | 132 | |
dc.contributor.firstauthorID | 220122 | |