Basit öğe kaydını göster

dc.contributor.authorSaglam, Esra
dc.contributor.authorCicin, Irfan
dc.contributor.authorKaragol, Hakan
dc.contributor.authorKucucuk, Seden
dc.contributor.authorDincer, Maktav
dc.contributor.authorYavuz, Ekrem
dc.contributor.authorAlas, Rusen Cosar
dc.contributor.authorEralp, Yesim
dc.contributor.authorTopuz, Erkan
dc.contributor.authorSaip, Pinar
dc.date.accessioned2021-03-05T15:05:36Z
dc.date.available2021-03-05T15:05:36Z
dc.date.issued2009
dc.identifier.citationSaip P., Cicin I., Eralp Y., Karagol H., Kucucuk S., Alas R. C. , Yavuz E., Dincer M., Saglam E., Topuz E., "Identification of patients who may benefit from the prophylactic cranial radiotherapy among breast cancer patients with brain metastasis", JOURNAL OF NEURO-ONCOLOGY, cilt.93, ss.243-251, 2009
dc.identifier.issn0167-594X
dc.identifier.otherav_ba5752be-9168-4a94-ae44-11414bb157fd
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/123943
dc.identifier.urihttps://doi.org/10.1007/s11060-008-9769-0
dc.description.abstractBackground To identify the candidates for prophylactic cranial radiotherapy (PCI) among the patients with early and advanced-stage breast cancer. Methods The demographic, pathologic and clinical features and survival results of 182 brain metastatic breast cancer patients treated with cranial radiotherapy were examined. Results Early stage patients who progressed with isolated brain metastasis had longer survival (13 months vs. 4 months P = 0.006). Lobular/mixed type histology (P = 0.033), high nuclear (P = 0.046) and high histological grade (P = 0.034) were the prognostic factors for isolated brain metastases. The most significant factor for the time to brain metastasis was the number of involved of lymph nodes (P = 0.004). In 60% of 148 patients with metastatic breast cancer, a progression with isolated brain metastasis was developed while the systemic disease was under control. Isolated brain metastasis progression was related to the presence of the hepatic metastasis at the first relapse (P = 0.001) and with ErbB-2 overexpression (P = 0.034). The time to the brain metastasis from the first extracerabral metastasis was associated with the high nuclear grade (P = 0.040) and with chemoresistance (P = 0.037). The median survival time after the brain metastases in chemosensitive patients was longer than in chemoresistant patients (8 months vs. 3 months P = 0.044). In chemoresistant patients (P = 0.0028) and/or in triple negative patients (P = 0.05) the development of the brain metastasis was early and the survival after brain metastasis was short. Discussions Since there is a tendency to early brain metastasis in early stage patients with high-grade, lobular/mixed type histology tumors and with a high number of involved lymph nodes, the value of PCI can be explored in these patients by a well designed prospective trial. Advanced stage chemosensitive patients with ErbB-2 over-expression and/or with hepatic metastasis at their first relapse may be candidates for PCI. There is no place for PCI in chemoresistant and triple-negative breast cancer patients.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectKLİNİK NEUROLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectNöroloji
dc.titleIdentification of patients who may benefit from the prophylactic cranial radiotherapy among breast cancer patients with brain metastasis
dc.typeMakale
dc.relation.journalJOURNAL OF NEURO-ONCOLOGY
dc.contributor.departmentTrakya Üniversitesi , ,
dc.identifier.volume93
dc.identifier.issue2
dc.identifier.startpage243
dc.identifier.endpage251
dc.contributor.firstauthorID30055


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster