Acetamiprid-induced Cyto- and Genotoxicity in the AR42J Pancreatic Cell Line

Abstract

Objectives: Neonicotinoid insecticides, 30% of insecticides marketed worldwide, have selective toxicity on insects through alpha 4p2 nicotinic acetylcholine receptors. Although it is known that acetamiprid exerts toxicity on several organ systems, its toxic effects on the pancreas and its mechanism of action have not been clarified yet. Therefore, in the present study, the cytotoxic and genotoxic potentials of acetamiprid on the AR42J pancreatic cell line were evaluated.