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Age-related changes in the rat hippocampus

dc.contributor.authorComunoglu, Nil
dc.contributor.authorIs, Merih
dc.contributor.authorCOMUNOGLU, Cem
dc.contributor.authorEren, Bulent
dc.contributor.authorEkici, Isin Dogan
dc.contributor.authorOzkan, Ferda
dc.date.accessioned2021-03-05T14:32:56Z
dc.date.available2021-03-05T14:32:56Z
dc.date.issued2008
dc.identifier.citationIs M., Comunoglu N., COMUNOGLU C., Eren B., Ekici I. D. , Ozkan F., "Age-related changes in the rat hippocampus", JOURNAL OF CLINICAL NEUROSCIENCE, cilt.15, ss.568-574, 2008
dc.identifier.issn0967-5868
dc.identifier.othervv_1032021
dc.identifier.otherav_b7b20b48-c914-45ae-b925-e6e8cfac1ec9
dc.identifier.urihttp://hdl.handle.net/20.500.12627/122244
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2007.03.025
dc.description.abstractThe human brain is uniquely powerful in its cognitive abilities, yet the hippocampal and neocortical circuits that mediate these complex functions are highly vulnerable during aging. In this study, we analyzed age-related changes in the rat hippocampus by studying newborn (1 month), middle-aged (12 months), and older (24 months) male and female Sprague-Dawley rats. We evaluated neuronal dystrophy, neuron scattering, and granulovacuolar degeneration in the hippocampal area using light microscopy, according to age and gender. We detected significant neuronal dystrophy in the CA1, CA2, and CA3 areas in male rats, and in the CA1, CA3, and CA4 areas in female rats. Degenerative changes, indicated by neuron scattering, were observed in the CA1, CA2, and CA3 areas of male and the CA2 and CA4 areas of female rats. Changes in all areas of the hippocampus were observed with increasing age; these changes included neuronal dystrophy and neuron scattering and did not differ significantly between male and female rats. (C) 2007 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectKLİNİK NEUROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.titleAge-related changes in the rat hippocampus
dc.typeMakale
dc.relation.journalJOURNAL OF CLINICAL NEUROSCIENCE
dc.contributor.departmentDüzce Üniversitesi , ,
dc.identifier.volume15
dc.identifier.issue5
dc.identifier.startpage568
dc.identifier.endpage574
dc.contributor.firstauthorID89966


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