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dc.contributor.authorBozbora, A
dc.contributor.authorGelisgen, Remise
dc.contributor.authorErbil, Yeşim
dc.contributor.authorSeven, Rıdvan
dc.contributor.authorSeven, Arzu Naciye
dc.contributor.authorBurcak, GÜLDEN
dc.date.accessioned2021-03-05T14:19:44Z
dc.date.available2021-03-05T14:19:44Z
dc.date.issued2001
dc.identifier.citationSeven R., Gelisgen R., Seven A. N. , Erbil Y., Bozbora A., Burcak G., "Influence of propylthiouracil treatment on oxidative stress and nitric oxide in Basedow disease patients", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, cilt.62, ss.495-503, 2001
dc.identifier.issn1528-7394
dc.identifier.otherav_b695626d-3f45-48c7-9ee8-6d88c9452eb2
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/121537
dc.identifier.urihttps://doi.org/10.1080/152873901300007806
dc.description.abstractOxidative stress parameters and nitric oxide (NO) values were determined in 27 newly diagnosed Basedow patients before and afer 1 mo of propylthiouracil (PTU) therapy and in 15 healthy controls. Basedow patients exhibited increased triiodothyronine (T-3) and thyroxine (T-4) and decreased thyroid-stimulating hormone (TSH) values compared to controls. Significantly higher thiobarbituric acid-reactive substances (TBARS), NO and glutathione (GSH) levels, and CuZn superoxide dismutase (CuZn SOD) activity were found in Basedow patients in comparison to controls, regardless of sex. Treatment with PTU (3 x 100 mg/d for 30 d) was effective in decreasing T-3 and T-4 and increasing TSH levels. Significantly decreased NO and TBARS and increased GSH and CuZn SOD levels were observed in PTU-treated Basedow patients compared to pre-PTU administration. PTU-treated patients compared to controls still exhibited significantly higher T-3 and lower TSH values and higher NO, TBARS, GSH, and CuZn SOD levels. The induced antioxidant defense and decrease in NO values in response to PTU therapy emphasizes the role of PTU as an antithyroid drug, where the ability to diminish hyperthyroidism results in decreased catabolism and lower oxidant generation.
dc.language.isoeng
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectSosyoloji
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectÇEVRE BİLİMLERİ
dc.subjectÇevre / Ekoloji
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.titleInfluence of propylthiouracil treatment on oxidative stress and nitric oxide in Basedow disease patients
dc.typeMakale
dc.relation.journalJOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume62
dc.identifier.issue7
dc.identifier.startpage495
dc.identifier.endpage503
dc.contributor.firstauthorID2654


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