dc.contributor.author | Gursoy, Aysel | |
dc.contributor.author | Klip, Nalan Terzioglu | |
dc.contributor.author | Capan, Gueltaze | |
dc.contributor.author | Satana, Dilek | |
dc.contributor.author | Uzun, Meltem | |
dc.date.accessioned | 2021-03-05T14:15:42Z | |
dc.date.available | 2021-03-05T14:15:42Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Klip N. T. , Capan G., Gursoy A., Uzun M., Satana D., "Synthesis, structure, and antifungal evaluation of some novel 1,2,4-triazolylmercaptoacetylthiosemicarbazide and 1,2,4-triazolylmercaptomethyl-1,3,4-thiadiazole analogs", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, sa.1, ss.126-131, 2010 | |
dc.identifier.issn | 1475-6366 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_b644b685-c323-4fd8-ac35-fc4897cabb6c | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/121332 | |
dc.identifier.uri | https://doi.org/10.3109/14756360903040439 | |
dc.description.abstract | Novel 1-[[4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazole-3-yl]mercaptoacetyl]-4-alkyl/aryl-3-thiosemicarbazides (5-12) were synthesized by the reaction of 4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazole-3-ylmercaptoacetylhydrazide (4) with substituted isothiocyanates. Cyclodehydration of thiosemicarbazides with concentrated sulfuric acid yielded 2-[4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazole-3-yl]mercaptomethyl-5-alkyl/arylamino-1,3,4-thiadiazoles (13-17). The new compounds were evaluated for in vitro antifungal activity using the microdilution method. The tested compounds showed varying degrees of activity against Microsporum gypseum NCPF-580, Microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum, and Candida albicans ATCC 10231 (MIC 8-4 mu g/mL). | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | KİMYA, TIP | |
dc.subject | Kimya | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Biyokimya | |
dc.subject | Temel Bilimler | |
dc.title | Synthesis, structure, and antifungal evaluation of some novel 1,2,4-triazolylmercaptoacetylthiosemicarbazide and 1,2,4-triazolylmercaptomethyl-1,3,4-thiadiazole analogs | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 25 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 126 | |
dc.identifier.endpage | 131 | |
dc.contributor.firstauthorID | 4921 | |