dc.contributor.author | GÜZEL, EDA ÇELİK | |
dc.contributor.author | Yuksel, Mehmet Aytac | |
dc.contributor.author | Abali, Remzi | |
dc.contributor.author | Guzel, Savas | |
dc.contributor.author | KIRAN, REBİAY | |
dc.contributor.author | ŞİKAR AKTÜRK, AYSUN | |
dc.date.accessioned | 2021-03-05T14:11:06Z | |
dc.date.available | 2021-03-05T14:11:06Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | ŞİKAR AKTÜRK A., Abali R., Yuksel M. A. , GÜZEL E. Ç. , Guzel S., KIRAN R., "The effects of isotretinoin on the ovarian reserve of females with acne", GYNECOLOGICAL ENDOCRINOLOGY, cilt.30, ss.30-33, 2014 | |
dc.identifier.issn | 0951-3590 | |
dc.identifier.other | av_b5ebaf71-740f-404a-8754-f67214195b37 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/121080 | |
dc.identifier.uri | https://doi.org/10.3109/09513590.2013.860118 | |
dc.description.abstract | There are some side effects of isotretinoin in many organs. However, a study investigating the effects of isotretinoin on the human ovarian reserve has not been reported previously. The study was conducted to investigate possible effects of isotretinoin on ovarian reserve. Serum anti-Mullerian hormone (AMH) levels were measured at the beginning and at the end of isotretinoin treatment in 22 patients with acne and in 22 women without. The mean AMH level before treatment was 5.77 ng/mL in the study group and 3.79 ng/mL in the control group (p =0.008). Following treatment, the mean AMH level was 4.69 ng/mL in the study group. This mean AMH level after treatment was statistically lower than the AMH level before treatment (p= 0.012). There was no significant difference between the mean AMH level at the end of treatment and that of the control group (p= 0.20). The high level of pre-treatment AMH levels could be an evidence of hyperandrogenism in women with acne, even if they are not identified as having polycystic ovary syndrome (PCOS) or hyperandrogenism. Decrease in AMH levels following exposure to isotretinoin may suggest that it has a detrimental effect on the ovaries. | |
dc.language.iso | eng | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Kadın Hastalıkları ve Doğum | |
dc.subject | Sağlık Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | KADIN HASTALIKLARI & DOĞUM | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.title | The effects of isotretinoin on the ovarian reserve of females with acne | |
dc.type | Makale | |
dc.relation.journal | GYNECOLOGICAL ENDOCRINOLOGY | |
dc.contributor.department | Kocaeli Üniversitesi , Tıp Fakültesi , Deri Ve Zührevi Hastalıklar | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 30 | |
dc.identifier.endpage | 33 | |
dc.contributor.firstauthorID | 212695 | |