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Mitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis

dc.contributor.authorGurses, Candan
dc.contributor.authorGokyigit, Aysen
dc.contributor.authorUstek, Duran
dc.contributor.authorCakiris, Aris
dc.contributor.authorKursun, Olcay
dc.contributor.authorAzakli, Hulya
dc.contributor.authorAlptekin, Ahmet
dc.contributor.authorAbaci, Neslihan
dc.contributor.authorArikan, Muzaffer
dc.date.accessioned2021-03-05T14:01:22Z
dc.date.available2021-03-05T14:01:22Z
dc.date.issued2014
dc.identifier.citationGurses C., Azakli H., Alptekin A., Cakiris A., Abaci N., Arikan M., Kursun O., Gokyigit A., Ustek D., "Mitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis", GENE, cilt.538, ss.323-327, 2014
dc.identifier.issn0378-1119
dc.identifier.othervv_1032021
dc.identifier.otherav_b508add5-2f7b-4bc3-bfa5-8e35be5fae5c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/120564
dc.identifier.urihttps://doi.org/10.1016/j.gene.2014.01.030
dc.description.abstractIntroduction: Mitochondria have an essential role in neuronal excitability and neuronal survival. In addition to energy production, mitochondria also play a crucial role in the maintenance of intracellular calcium homeostasis, generation of reactive oxygen species and mechanisms of cell death. There is a relative paucity of data about the role of mitochondria in epilepsy. Mitochondrial genome analysis is rarely carried out in the investigation of some diseases. In mesial temporal lobe epilepsies (MTLE) cases, genome analysis has never been used previously. The aim of this study is to show mitochondrial dysfunctions using genome analysis in patients with MTLE-hippocampal sclerosis (HS).
dc.language.isoeng
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectGENETİK VE HAYAT
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.titleMitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis
dc.typeMakale
dc.relation.journalGENE
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume538
dc.identifier.issue2
dc.identifier.startpage323
dc.identifier.endpage327
dc.contributor.firstauthorID171


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