Show simple item record

dc.contributor.authorAltin, Remzi
dc.contributor.authorArmutcu, FERAH
dc.contributor.authorGurel, Ahmet
dc.contributor.authorGun, Banu Dogan
dc.date.accessioned2021-03-02T21:50:41Z
dc.date.available2021-03-02T21:50:41Z
dc.date.issued2007
dc.identifier.citationArmutcu F., Gun B. D. , Altin R., Gurel A., "Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience", ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.24, sa.2, ss.106-113, 2007
dc.identifier.issn1382-6689
dc.identifier.othervv_1032021
dc.identifier.otherav_09364cf5-af4f-4d0e-8e05-04c0d7a10835
dc.identifier.urihttp://hdl.handle.net/20.500.12627/12006
dc.identifier.urihttps://doi.org/10.1016/j.etap.2007.03.002
dc.description.abstractOccupational exposure to coal dust causes pneumoconiosis and other diseases. Reactive oxygen species (ROS) have been implicated in the pathogenesis of coal dust-induced lung toxicity. In this experimental study, we investigated the oxidant/antioxidant status, nitric oxide (NO) and hydroxyproline (HP) levels in lungs and blood of rats exposed to coal dust in mine ambience. In addition, we also investigated the attenuating effects of erdosteine. At the end of the experiment processes, tissue levels of HP, malondialdehyde (MDA) and NO, as well as the activities of superoxide dismutase, glutathione peroxidase, catalase, xanthine oxidase (XO), myeloperoxidase (MPO) and proinflammatory cytokines (IL-6 and TNF-alpha) were evaluated in the lung tissues, plasma samples or erythrocytes of rats. Exposure to coal dust resulted in a significant increase in the oxidant parameters (MDA, NO levels, and XO activity) and HP levels, as compared to the controls. A decrease in activities of antioxidant enzymes, and an increase in MPO activity were found in the study group, compared to the controls. Increased NO levels of lung were found in the study groups, that were significantly reduced by erdosteine. Our studies provide evidence that supports the hypothesis for ROS mediated coal workers' pneumocomosis. Erdosteine may be beneficial in the coal dust-induced lung toxicity via antioxidant and free radical scavenger properties. (c) 2007 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectTOKSİKOLOJİ
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectÇevre / Ekoloji
dc.subjectÇEVRE BİLİMLERİ
dc.titleExamination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience
dc.typeMakale
dc.relation.journalENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
dc.contributor.department, ,
dc.identifier.volume24
dc.identifier.issue2
dc.identifier.startpage106
dc.identifier.endpage113
dc.contributor.firstauthorID95046


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record