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dc.contributor.authorBaca, B
dc.contributor.authorKarahasanoglu, T
dc.contributor.authorPekmezci, S
dc.contributor.authorSaribeyoglu, K
dc.contributor.authorHamzaoglu, I
dc.contributor.authorHamzaoglu, H
dc.date.accessioned2021-03-05T13:47:12Z
dc.date.available2021-03-05T13:47:12Z
dc.date.issued2003
dc.identifier.citationSaribeyoglu K., Baca B., Hamzaoglu I., Pekmezci S., Karahasanoglu T., Hamzaoglu H., "Does becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis?", DISEASES OF THE COLON & RECTUM, cilt.46, ss.516-520, 2003
dc.identifier.issn0012-3706
dc.identifier.othervv_1032021
dc.identifier.otherav_b3e274a0-c8fc-493b-9501-de401cdebeb0
dc.identifier.urihttp://hdl.handle.net/20.500.12627/119799
dc.identifier.urihttps://doi.org/10.1097/01.dcr.0000054663.95931.a0
dc.description.abstractPurpose: The aim of this study was to evaluate the effects of becaplermin on normal and ischemic colon anastomoses. Methods: Forty adult male Wistar-Albino rats were divided into four equal groups of ten. AD rats underwent standard left colon resection and end-to end anastomosis. The groups were as follows: Group 1, normal anastomosis alone; Group 2, ischemic anastomosis alone; Group 3, normal anastomosis and becaplermin therapy, and Group 4, ischemic anastomosis and becaplermin therapy. All animals were killed on postoperative Day 4. Intra-abdominal adhesions were scored, and anastomotic healing was evaluated with both in situ bursting pressure and hydroxyproline levels. Results: According to bursting pressure results, there was a significant difference between Group 2 and Group 4 (P0.05). Hydroxyproline values revealed no statistically significant difference among any of the groups (P>0.05). With regard to intra-abdominal adhesion scores, Group 3 had significantly lower values than Group 2 and Group 4 (P<0.05). No statistically significant difference was observed between the other groups. Conclusions: Detrimental effects of ischemia on colonic anastomotic healing were reversed with becaplermin therapy. However there was no such benefit on nonischemic anastomoses. Intra-abdominal application of this gel did not lead to an increase in intra-abdominal adhesion formation.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectCerrahi Tıp Bilimleri
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectCERRAHİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.titleDoes becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis?
dc.typeMakale
dc.relation.journalDISEASES OF THE COLON & RECTUM
dc.contributor.department, ,
dc.identifier.volume46
dc.identifier.issue4
dc.identifier.startpage516
dc.identifier.endpage520
dc.contributor.firstauthorID168089


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