dc.contributor.author | Baca, B | |
dc.contributor.author | Karahasanoglu, T | |
dc.contributor.author | Pekmezci, S | |
dc.contributor.author | Saribeyoglu, K | |
dc.contributor.author | Hamzaoglu, I | |
dc.contributor.author | Hamzaoglu, H | |
dc.date.accessioned | 2021-03-05T13:47:12Z | |
dc.date.available | 2021-03-05T13:47:12Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Saribeyoglu K., Baca B., Hamzaoglu I., Pekmezci S., Karahasanoglu T., Hamzaoglu H., "Does becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis?", DISEASES OF THE COLON & RECTUM, cilt.46, ss.516-520, 2003 | |
dc.identifier.issn | 0012-3706 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_b3e274a0-c8fc-493b-9501-de401cdebeb0 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/119799 | |
dc.identifier.uri | https://doi.org/10.1097/01.dcr.0000054663.95931.a0 | |
dc.description.abstract | Purpose: The aim of this study was to evaluate the effects of becaplermin on normal and ischemic colon anastomoses. Methods: Forty adult male Wistar-Albino rats were divided into four equal groups of ten. AD rats underwent standard left colon resection and end-to end anastomosis. The groups were as follows: Group 1, normal anastomosis alone; Group 2, ischemic anastomosis alone; Group 3, normal anastomosis and becaplermin therapy, and Group 4, ischemic anastomosis and becaplermin therapy. All animals were killed on postoperative Day 4. Intra-abdominal adhesions were scored, and anastomotic healing was evaluated with both in situ bursting pressure and hydroxyproline levels. Results: According to bursting pressure results, there was a significant difference between Group 2 and Group 4 (P0.05). Hydroxyproline values revealed no statistically significant difference among any of the groups (P>0.05). With regard to intra-abdominal adhesion scores, Group 3 had significantly lower values than Group 2 and Group 4 (P<0.05). No statistically significant difference was observed between the other groups. Conclusions: Detrimental effects of ischemia on colonic anastomotic healing were reversed with becaplermin therapy. However there was no such benefit on nonischemic anastomoses. Intra-abdominal application of this gel did not lead to an increase in intra-abdominal adhesion formation. | |
dc.language.iso | eng | |
dc.subject | İç Hastalıkları | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Gastroenteroloji-(Hepatoloji) | |
dc.subject | GASTROENTEROLOJİ VE HEPATOLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | CERRAHİ | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.title | Does becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis? | |
dc.type | Makale | |
dc.relation.journal | DISEASES OF THE COLON & RECTUM | |
dc.contributor.department | , , | |
dc.identifier.volume | 46 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 516 | |
dc.identifier.endpage | 520 | |
dc.contributor.firstauthorID | 168089 | |