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Ocular and generalized myasthenia gravis induced by human acetylcholine receptor ? subunit immunization

dc.contributor.authorTuzun, Erdem
dc.contributor.authorWU, Xiaorong
dc.contributor.authorLI, Jing
dc.contributor.authorXIAO, Tianlin
dc.contributor.authorSAINI, Shamsher S.
dc.contributor.authorQI, Huibin
dc.contributor.authorALLMAN, Windy
dc.contributor.authorCHRISTADOSS, Premkumar
dc.date.accessioned2021-03-05T13:36:41Z
dc.date.available2021-03-05T13:36:41Z
dc.date.issued2012
dc.identifier.citationWU X., Tuzun E., LI J., XIAO T., SAINI S. S. , QI H., ALLMAN W., CHRISTADOSS P., "Ocular and generalized myasthenia gravis induced by human acetylcholine receptor ? subunit immunization", MUSCLE & NERVE, cilt.45, ss.209-216, 2012
dc.identifier.issn0148-639X
dc.identifier.othervv_1032021
dc.identifier.otherav_b301d34f-25c3-4b8a-a893-8b9b9a04a489
dc.identifier.urihttp://hdl.handle.net/20.500.12627/119244
dc.identifier.urihttps://doi.org/10.1002/mus.22273
dc.description.abstractIntroduction: HLA-DQ8 transgenic mice develop ocular myasthenia gravis (oMG), which then progresses to generalized MG (gMG) when immunized with the human acetylcholine receptor (H-AChR) a subunit. Because the fetal AChR ? subunit is expressed in adult extraocular muscles, we anticipated that ? subunit immunization would generate an immune response to mouse AChR and induce MG in mice. Results: H-AChR ? subunit immunization in HLA-DQ8 mice induced an autoimmune response to mouse AChR and led to the destruction of AChR in the neuromuscular junction (NMJ) by anti-AChR antibody and complement activation, and it triggered upregulation of AChR gene transcription. Conclusion: Our findings indicate that oMG may be induced by immunity to the AChR ? subunit. Muscle Nerve, 2012
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectKLİNİK NEUROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectNöroloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleOcular and generalized myasthenia gravis induced by human acetylcholine receptor ? subunit immunization
dc.typeMakale
dc.relation.journalMUSCLE & NERVE
dc.contributor.department, ,
dc.identifier.volume45
dc.identifier.issue2
dc.identifier.startpage209
dc.identifier.endpage216
dc.contributor.firstauthorID2351


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