Central nervous system infection due to Penicillium chrysogenum

Abstract

Penicillium chrysogenum was isolated from three subsequent cerebrospinal fluid (CSF) specimens of a 73-year-old male patient without immunological compromise. The isolated was tested against five antifungal agents according to the NCCLS M38-P macrodilution method. MICs were determined as follows: amphotericin B (AMB), 2 mug ml(-1); fluconazole (FLZ), 8 mug ml(-1); itraconazole (ITZ), 1 mug ml(-1); flucytosine (5FC), 0.125 mug ml(-1); and terbinafine (TRB), 0.06 mug ml(-1). The patient has been cured with FLZ.