dc.contributor.author | Oztunc, Funda | |
dc.contributor.author | Kasapcopur, Ozgur | |
dc.contributor.author | Adrovic, Amra | |
dc.contributor.author | Sahin, Sezgin | |
dc.contributor.author | Dedeoglu, Reyhan | |
dc.contributor.author | Barut, Kenan | |
dc.date.accessioned | 2021-03-05T13:06:16Z | |
dc.date.available | 2021-03-05T13:06:16Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Dedeoglu R., Adrovic A., Oztunc F., Sahin S., Barut K., Kasapcopur O., "New Insights into Cardiac Involvement in Juvenile Scleroderma: A Three-Dimensional Echocardiographic Assessment Unveils Subclinical Ventricle Dysfunction", PEDIATRIC CARDIOLOGY, cilt.38, ss.1686-1695, 2017 | |
dc.identifier.issn | 0172-0643 | |
dc.identifier.other | av_b087af95-63f1-4cec-8667-1c552d32d0d3 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/117675 | |
dc.identifier.uri | https://doi.org/10.1007/s00246-017-1714-6 | |
dc.description.abstract | Cardiac manifestations in juvenile scleroderma or systemic sclerosis (JSSc) have poor prognosis, begin in early stages of the disease, and remain clinically asymptomatic. New echocardiography modalities, such as 2D/3D speckle tracking (STE, strain analysis for regional and global ventricular functions), can detect cardiac involvement in early stages. We assessed 21 JSSc patients and 19 controls using 2D/3D STE. The left ventricular end diastolic volume, end systolic volume, and ejection fraction of the patient and control groups were significantly different (99.2 +/- 23.8 vs. 52 +/- 23.8, 40.6 +/- 16.0 vs. 20.2 +/- 17.4 and 59.2 +/- 7.5 vs. 65.6 +/- 5.2, respectively). Global longitudinal strain (GLS) and global circumferential strain (GCS) were lower in the patient group (18.4 +/- 4.7 vs. 22.4 +/- 3.7, 26.4 +/- 5.8 vs. 31.4 +/- 3.5), as were the peak systolic strain values of the right ventricular longitudinal strain (RVLS) septum and RVLS free wall (18.1 +/- 6.8 vs. 24.8 +/- 6.0 and 22.8 +/- 5.9 vs. 28.0 +/- 6.9, respectively). 3D measurements of RVEDV, RVESV, and RVSV were higher in the patient group (88.2 +/- 31.3 vs. 50.8 +/- 23.5, 43.1 +/- 17.6 vs. 19.0 +/- 12.2, and 45.0 +/- 16.2 vs. 31.7 +/- 12.6). RVLS freewall results were lower in the JSSc patients with interstitial lung fibrosis, arthritis, muscle weakness, weight loss, and anti-scl 70 antibodies than in the JSSc patients without these variables. We found that a GCS of < 34.5% could identify patients for left ventricular (LV) dysfunction with a sensitivity of 93.3, specificity of 92.9, while an RVEF of < 60.7% could identify patients for left ventricular (RV) dysfunction with a sensitivity of 92.9 and specificity of 21.4%. We highlighted key advantages of 3D STE for the tracking of early systolic dysfunction in patients with JSSc who would benefit from medical intervention for cardiac complications. | |
dc.language.iso | eng | |
dc.subject | Çocuk Sağlığı ve Hastalıkları | |
dc.subject | Kardiyoloji | |
dc.subject | PEDİATRİ | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | CARDIAC ve CARDIOVASCULAR SİSTEMLER | |
dc.title | New Insights into Cardiac Involvement in Juvenile Scleroderma: A Three-Dimensional Echocardiographic Assessment Unveils Subclinical Ventricle Dysfunction | |
dc.type | Makale | |
dc.relation.journal | PEDIATRIC CARDIOLOGY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 38 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 1686 | |
dc.identifier.endpage | 1695 | |
dc.contributor.firstauthorID | 43017 | |