Show simple item record

dc.contributor.authorSenturk, Umit Kemal
dc.contributor.authorUlker, Seher Nasircilar
dc.contributor.authorSati, Leyla
dc.contributor.authorÖZEN, NUR
dc.contributor.authorBASRALI, FİLİZ
dc.contributor.authorKocer, Gunnur
dc.contributor.authorÖzyurt, Dilek
dc.contributor.authorKaradamar, Pinar Ulker
dc.date.accessioned2021-03-05T12:30:39Z
dc.date.available2021-03-05T12:30:39Z
dc.date.issued2015
dc.identifier.citationBASRALI F., Kocer G., Karadamar P. U. , Ulker S. N. , Sati L., ÖZEN N., Özyurt D., Senturk U. K. , "Effect of magnesium supplementation on blood pressure and vascular reactivity in nitric oxide synthase inhibition-induced hypertension model", CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.37, ss.633-642, 2015
dc.identifier.issn1064-1963
dc.identifier.otherav_ad911ee6-b0af-4835-8fee-40b5f2672f9c
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/115799
dc.identifier.urihttps://doi.org/10.3109/10641963.2015.1036063
dc.description.abstractThe aim of this study was to assess the effect of oral magnesium supplementation (Mg-supp) on blood pressure (BP) and possible mechanism in nitric oxide synthase (NOS) inhibition-induced hypertension model. Hypertension and/or Mg-supp were created by N-nitro-l-arginine methyl ester (25mg/kg/day by drinking water) and magnesium-oxide (0.8% by diet) for 6 weeks. Systolic BP was measured weekly by tail-cuff method. The effects of hypertension and/or Mg-supp in thoracic aorta and third branch of mesenteric artery constriction and relaxation responses were evaluated. NOS-inhibition produced a gradually developing hypertension and the magnitude of the BP was significantly attenuated after five weeks of Mg-supp. The increased phenylephrine-induced contractile and decreased acetylcholine (ACh)-induced dilation responses were found in both artery segments of hypertensive groups. Mg-supp was restored ACh-relaxation response in both arterial segments and also Phe-constriction response in thoracic aorta but not in mesenteric arteries. The contributions of NO, prostaglandins and K+ channels to the dilator response of ACh were similar in the aorta of all the groups. The contribution of the NO to the ACh-mediated relaxation response of mesenteric arteries was suppressed in hypertensive rats, whereas this was corrected by Mg-supp. The flow-mediated dilation response of mesenteric arteries in hypertensive rats failed and could not be corrected by Mg-supp. Whereas, vascular eNOS protein and magnesium levels were not changed and plasma nitrite levels were reduced in hypertensive rats. The results of this study showed that Mg-supp lowered the arterial BP in NOS-inhibition induced hypertension model by restoring the agonist-induced relaxation response of the arteries.
dc.language.isoeng
dc.subjectTıp
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleEffect of magnesium supplementation on blood pressure and vascular reactivity in nitric oxide synthase inhibition-induced hypertension model
dc.typeMakale
dc.relation.journalCLINICAL AND EXPERIMENTAL HYPERTENSION
dc.contributor.departmentAkdeniz Üniversitesi , Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.identifier.volume37
dc.identifier.issue8
dc.identifier.startpage633
dc.identifier.endpage642
dc.contributor.firstauthorID2182000


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record