dc.contributor.author | Dalcik, H | |
dc.contributor.author | Yucesoy, I | |
dc.contributor.author | Erk, A | |
dc.contributor.author | Dalcik, C | |
dc.contributor.author | Vural, F | |
dc.contributor.author | Vural, B | |
dc.contributor.author | Solakoglu, S | |
dc.date.accessioned | 2021-03-05T12:16:35Z | |
dc.date.available | 2021-03-05T12:16:35Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Vural B., Solakoglu S., Dalcik H., Vural F., Dalcik C., Erk A., Yucesoy I., "Antiproliferative effects and insulin-like growth factor-I expression in Balb-C 3T3 fibroblasts after treatment with somatostatin and gonadotropin-releasing hormone analogs", ACTA HISTOCHEMICA, cilt.102, ss.353-363, 2000 | |
dc.identifier.issn | 0065-1281 | |
dc.identifier.other | av_ac61dbd9-0acf-4f41-bbb8-8fe6af80691a | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/115038 | |
dc.identifier.uri | https://doi.org/10.1078/s0065-1281(04)70041-0 | |
dc.description.abstract | The present study was aimed to compare antiproliferative effects of somatostatin (SS) and gonadotropin-releasing hormone analogs (GnRHa) on a fibroblast cell line. Proliferation index, cell count, viability of the cells and insulin-like growth factor-I (IGF-I) immunoreactivity were determined after treatment with either SS (100 mu M/ml), GnRHa (35 nM/ml) or SS and GnRHa of Balb-C 3T3 mouse fibroblasts. It was found that the proliferation index, cell count, viability and IGF-I immunoreactivity were not affected by GnRHa treatment as compared with no treatment (p > 0.05). Application of SS to the fibroblasts resulted in a significant reduction in proliferation index, cell count, and IGF-I immunoreactivity as compared with GnRHa treatment and no treatment, but it had no effect on cell viability. The labelling index in SS-treated cells was significantly reduced as compared with combined treatment with SS and GnRHa. In conclusion, a direct effect of GnRHa on fibroblast cells in culture could not be demonstrated. SS had direct inhibitory effects on cell proliferation possibly via inhibition of IGF-I effects without affecting cell viability. | |
dc.language.iso | eng | |
dc.subject | Histoloji-Embriyoloji | |
dc.subject | Temel Bilimler | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | HÜCRE BİYOLOJİSİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Tıp | |
dc.title | Antiproliferative effects and insulin-like growth factor-I expression in Balb-C 3T3 fibroblasts after treatment with somatostatin and gonadotropin-releasing hormone analogs | |
dc.type | Makale | |
dc.relation.journal | ACTA HISTOCHEMICA | |
dc.contributor.department | , , | |
dc.identifier.volume | 102 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 353 | |
dc.identifier.endpage | 363 | |
dc.contributor.firstauthorID | 126252 | |