dc.contributor.author | OZKAN, O | |
dc.contributor.author | BAKTIR, Gül | |
dc.contributor.author | DAGOGLU, G | |
dc.contributor.author | Keles, Oya | |
dc.contributor.author | Bakirel, Tülay | |
dc.contributor.author | SENER, S | |
dc.date.accessioned | 2021-03-05T11:38:13Z | |
dc.date.available | 2021-03-05T11:38:13Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Keles O., Bakirel T., SENER S., BAKTIR G., DAGOGLU G., OZKAN O., "Pharmacokinetics and tissue levels of tilmicosin in fowls", TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, cilt.25, ss.629-634, 2001 | |
dc.identifier.issn | 1300-0128 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_a92b202c-7929-4d96-922b-f18abbbb80c4 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/113002 | |
dc.description.abstract | Tilmicosin is a long-acting macrolide antibiotic used in the treatment of respiratory disease. It was administered once (SO mg/kg b.wt) to fowls via the oral route for determination of kinetic properties and tissue levels. After oral administration, tilmicosin's pharmacokinetics conformed to a two compartment open model. Tilmicosin was slowly eliminated from the serum and lung with mean half-lives of 30.18 +/- 2.38 and 75.74 +/- 3.67 hours, respectively The mean maximum concentration of the drug in the lungs was found to be 6.2 times greater that of serum. Serum and lung tilmicosin concentrations reached peak Values 4.66 +/- 2 and 17.78 +/- 7.51 hours, respectively, after oral administration. In fowls, the apparent volume of distribution was found to be more than 1 L/kg, indicating extensive tissue distribution. The clearance Values were calculated to be 1.33 +/- 0.06 for serum and 0.11 +/- 0.004 Vh for lung. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Veteriner Bilimleri | |
dc.subject | Tarımsal Bilimler | |
dc.subject | Tarım ve Çevre Bilimleri (AGE) | |
dc.subject | Bitki ve Hayvan Bilimleri | |
dc.subject | VETERİNERLİK BİLİMLERİ | |
dc.title | Pharmacokinetics and tissue levels of tilmicosin in fowls | |
dc.type | Makale | |
dc.relation.journal | TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES | |
dc.contributor.department | , , | |
dc.identifier.volume | 25 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 629 | |
dc.identifier.endpage | 634 | |
dc.contributor.firstauthorID | 45455 | |