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The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis

dc.contributor.authorNılsson, Ja
dc.contributor.authorBrennan, Ja
dc.contributor.authorBoyd, K
dc.contributor.authorCleveland, Jl
dc.contributor.authorGrosveld, Gc
dc.contributor.authorOzbek, Uğur
dc.contributor.authorSirma, Sema
dc.contributor.authorCardone, M
dc.contributor.authorKandılcı, A
dc.contributor.authorCarella, C
dc.date.accessioned2021-03-05T11:09:18Z
dc.date.available2021-03-05T11:09:18Z
dc.identifier.citationCardone M., Kandılcı A., Carella C., Nılsson J., Brennan J., Sirma S., Ozbek U., Boyd K., Cleveland J., Grosveld G., "The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis", MOLECULAR AND CELLULAR BIOLOGY, cilt.25, ss.2395-2405, 2005
dc.identifier.issn0270-7306
dc.identifier.otherav_a6c18dd8-7667-4a60-8d9b-d5a1055ea1cb
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/111497
dc.identifier.urihttps://doi.org/10.1128/mcb.25.6.2395-2405.2005
dc.description.abstractThe human ETS family gene TEL2/ETV7 is highly homologous to TELI/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and WC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.titleThe novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis
dc.typeMakale
dc.relation.journalMOLECULAR AND CELLULAR BIOLOGY
dc.contributor.department, ,
dc.identifier.volume25
dc.identifier.startpage2395
dc.identifier.endpage2405
dc.contributor.firstauthorID806231


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