Comparison of insulin resistance in the various stages of chronic kidney disease and inflammation

Abstract

Objective: In this study, we compared predialysis and dialysis patients with the controls in terms of insulin resistance and evaluated the association with inflammation that is a risk factor for cardiovascular disease. Materials and methods: A total of 134 non-diabetic patients with controls (n = 33), predialysis (n = 29) and dialysis patient group (n = 72) were included in the study. Fasting blood glucose, insulin, C-peptide, albumin, CRP (C-reactive protein) and homocysteine plasma levels were simultaneously analyzed in all the patients. HOMA-IR index was calculated to show existence of insulin resistance. Results: Mean insulin and HOMA-IR index values were found to be higher in the predialysis and dialysis patient groups than in the control group (p = 0.019, p = 0.014; respectively). When three groups were compared in terms of C-peptide levels; these values were found to be statistically significantly higher in the predialysis patients than in controls (p = 0.017) and in the dialysis group than in the predialysis patients and controls (p = 0.0001, p = 0.0001; respectively). CRP and homocysteine levels were found to be statistically higher (p = 0.0001, p = 0.0001; respectively), while albumin levels were significantly lower (p = 0.0001) in the dialysis patient group. Conclusion: In our study, we demonstrated that insulin resistance was higher in patients in the various stages of chronic kidney disease compared to healthy population. We found that insulin resistance, C-peptid and inflammation related cardiovascular risk factors increased.