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dc.contributor.authorKarali, N
dc.contributor.authorEkinci, AC
dc.contributor.authorOzer, H
dc.contributor.authorOzkirimli, S
dc.contributor.authorTerzioglu, N
dc.contributor.authorGursoy, A
dc.date.accessioned2021-03-05T09:52:48Z
dc.date.available2021-03-05T09:52:48Z
dc.identifier.citationKarali N., Gursoy A., Terzioglu N., Ozkirimli S., Ozer H., Ekinci A., "Synthesis and preliminary CNS depressant activity evaluation of new 3-[(3-substituted-5-methyl-4-thiazolidinon-2-ylidene)hydrazono]-1H-2-indolinones and 3-[(2-thioxo-3-substituted-4,5-imidazolidine-dion-1-yl)imino]-1H-2-indolinones", ARCHIV DER PHARMAZIE, cilt.331, ss.254-258, 1998
dc.identifier.issn0365-6233
dc.identifier.otherav_a0153c87-3a9a-4513-be3e-5d4a29f11c5e
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/107390
dc.description.abstractA series of (+/-) 3-[(3-substituted-5-methyl-4-thiazolidinon-2- ylidene)hydrazono]-1H-2-indolinones (2a-h) and 3-[(2-thioxo-3-substituted-4,5- imidazolidinedion-1-yl)imino]-1H-2-indolinones (3a-g) were synthesized by the cyclization of 3-(4-substituted-thiosemicarbazono)-1H-2-indolinones (la-h) with ethyl 2-bromopropionate in anhydrous ethanolic medium and oxalyl chloride in anhydrous diethyl ether, respectively. The structures of 2 and 3 were confirmed by analytical and spectral data (IR, H-1 NMR, C-13 NMR, and EIMS) The configuration of 3 was assigned on the basis of H-1 NMR and C-13 NMR data. 2c, 2d, 2g, 2h, and 3a-g were evaluated for anticonvulsant activity against maximal electroshock (MES) and subcutaneous pentylenetetrazol (ScMet) induced seizures. Among the compounds tested, only 2d exhibited some activity in anticonvulsant identification (Phase I) trials in mice. 2a, 2b, 2d, 2g, 2h, and 3a-g were additionally tested for potentiating effects on pentobarbital induced hypnosis in mice. All of the test compounds increased the sleeping time of pentobarbital significantly (p < 0.05) and the most potent compound was found to be 3a.
dc.language.isoeng
dc.subjectKimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectKİMYA, TIP
dc.subjectTemel Bilimler (SCI)
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.titleSynthesis and preliminary CNS depressant activity evaluation of new 3-[(3-substituted-5-methyl-4-thiazolidinon-2-ylidene)hydrazono]-1H-2-indolinones and 3-[(2-thioxo-3-substituted-4,5-imidazolidine-dion-1-yl)imino]-1H-2-indolinones
dc.typeMakale
dc.relation.journalARCHIV DER PHARMAZIE
dc.contributor.department, ,
dc.identifier.volume331
dc.identifier.startpage254
dc.identifier.endpage258
dc.contributor.firstauthorID120935


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