dc.contributor.author | Guler, Mehmet Ali | |
dc.contributor.author | Ozgumus, Saadet | |
dc.contributor.author | GÖK, Mehmet Koray | |
dc.date.accessioned | 2021-03-05T09:41:56Z | |
dc.date.available | 2021-03-05T09:41:56Z | |
dc.identifier.citation | Guler M. A. , GÖK M. K. , Ozgumus S., "Effects of the Starch Types and the Grafting Conditions on the In Vitro Mucoadhesiveness of the Starch-graft-Poly(Methacrylic Acid) Hydrogels", STARCH-STARKE, cilt.72, 2020 | |
dc.identifier.issn | 0038-9056 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_9f16ee98-5351-452f-9672-9fe82f96ef9d | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/106820 | |
dc.identifier.uri | https://doi.org/10.1002/star.201900266 | |
dc.description.abstract | In the present study, grafting of poly(methacrylic acid) (PMAA) onto various types of starches (maize; rice; wheat; potato) is realized in the aqueous media for the first time using methacrylic acid as monomer and ammonium cerium-IV-nitrate as initiator system. The effects of the gelatinization pretreatment and the use of a crosslinker in the grafting reactions are investigated. The formation of the starch-graft-poly(methacrylic acid) (S-g-PMAA) is confirmed by Fourier transform infrared spectroscopy analysis. The grafting amounts (GA%) of the S-g-PMAAs are determined. The swelling and the erosion characteristics of the S-g-PMAAs are examined in deionized water and pH = 5 lactate buffer solution as an in vitro vaginal medium. Mechanical and in vitro mucoadhesiveness of the S-g-PMAAs are also investigated using ewe vaginal mucosa. The results demonstrate that the gelatinization pretreatment and crosslinking significantly affect the GA% values, swelling, erosion, mechanical, and mucoadhesive characteristics of the S-g-PMAAs depending on the types of starches. S-g-PMAAs with different mechanical and reasonable mucoadhesiveness can be obtained by manipulating the grafting conditions and using various types of starches. It is concluded that S-g-PMAAs could be appropriate candidates for applications as vaginal drug delivery systems. | |
dc.language.iso | eng | |
dc.subject | Mühendislik ve Teknoloji | |
dc.subject | Ziraat | |
dc.subject | Gıda Mühendisliği | |
dc.subject | Tarım ve Çevre Bilimleri (AGE) | |
dc.subject | Tarımsal Bilimler | |
dc.subject | Tarım Bilimleri | |
dc.subject | GIDA BİLİMİ VE TEKNOLOJİSİ | |
dc.title | Effects of the Starch Types and the Grafting Conditions on the In Vitro Mucoadhesiveness of the Starch-graft-Poly(Methacrylic Acid) Hydrogels | |
dc.type | Makale | |
dc.relation.journal | STARCH-STARKE | |
dc.contributor.department | Elif Plast AC , , | |
dc.identifier.volume | 72 | |
dc.contributor.firstauthorID | 2284103 | |