dc.contributor.author | OZTAS, B | |
dc.date.accessioned | 2021-03-05T08:55:18Z | |
dc.date.available | 2021-03-05T08:55:18Z | |
dc.date.issued | 1995 | |
dc.identifier.citation | OZTAS B., "INFLUENCE OF ACUTE EXPOSURE TO HEAT ON THE BLOOD-BRAIN-BARRIER PERMEABILITY DURING ACUTE HYPERTENSION", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.52, ss.375-378, 1995 | |
dc.identifier.issn | 0091-3057 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_9b5a011c-b056-4025-9362-4aeaa9932a95 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/104428 | |
dc.identifier.uri | https://doi.org/10.1016/0091-3057(95)00121-c | |
dc.description.abstract | In mild hyperthermic rats with acute hypertension induced by intravenous injection of adrenaline, changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indicator. Evans blue albumin extravasation was determined macroscopically, and a quantitative estimation with spectrophotometer using homogenized brain to release the dye was also performed to evaluate the macroscopic findings. Four groups of rats were studied: group I: control normothermia; group II: acute exposure to heat; group III: normothermia + acute hypertension; group IV: acute exposure to heat + acute hypertension. The rats were anesthetized with diethyl-ether. Body temperature was increased by elevating ambient temperature in the vented box covered with a 3 mm thick black copper plate. The colonic temperature was increased to 39 +/- 0.5 degrees C. During adrenaline-induced acute hypertension the mean arterial blood pressure increased in both normothermic and mild hyperthermic animals. Mean values for Evans blue dye were found to be 0.20 +/- 0.04 mg% whole brain in normothermic control rats and 0.30 +/- 0.1 mg% in hyperthermic rats (p < 0.05). Mean values for Evans blue dye in the whole brain were found to be 0.63 +/- 0.2 mg% in the normothermic rats and 0.40 +/- 0.2 mg% in the mild hyperthermic rats during adrenaline-induced hypertension (p < 0.05). Our results show that the extravasation of Evans blue albumin was less pronounced in the brains of mild hyperthermic rats compared to normothermic rats after adrenaline-induced acute hypertension. | |
dc.language.iso | eng | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Sosyal ve Beşeri Bilimler | |
dc.subject | Davranış Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | NEUROSCIENCES | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | DAVRANIŞ BİLİMLERİ | |
dc.title | INFLUENCE OF ACUTE EXPOSURE TO HEAT ON THE BLOOD-BRAIN-BARRIER PERMEABILITY DURING ACUTE HYPERTENSION | |
dc.type | Makale | |
dc.relation.journal | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | |
dc.contributor.department | , , | |
dc.identifier.volume | 52 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 375 | |
dc.identifier.endpage | 378 | |
dc.contributor.firstauthorID | 116620 | |