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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

dc.contributor.authorDomschke, Katharina
dc.contributor.authorPaciga, Sara A.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorPerlis, Roy H.
dc.contributor.authorPorteous, David J.
dc.contributor.authorPotash, James B.
dc.contributor.authorPreisig, Martin
dc.contributor.authorRietschel, Marcella
dc.contributor.authorSchaefer, Catherine
dc.contributor.authorSchulze, Thomas G.
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorStefansson, Kari
dc.contributor.authorTiemeier, Henning
dc.contributor.authorUher, Rudolf
dc.contributor.authorVoelzke, Henry
dc.contributor.authorWeissman, Myrna M.
dc.contributor.authorWerge, Thomas
dc.contributor.authorLewis, Cathryn M.
dc.contributor.authorLevinson, Douglas F.
dc.contributor.authorBreen, Gerome
dc.contributor.authorBorglum, Anders D.
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorDirek, Neşe
dc.contributor.authorCzamara, Darina
dc.contributor.authorEraslan, Goekcen
dc.contributor.authorPage, Christian M.
dc.contributor.authorLahti, Jari
dc.contributor.authorLahti-Pulkkinen, Marius
dc.contributor.authorHamalainen, Esa
dc.contributor.authorKajantie, Eero
dc.contributor.authorLaivuori, Hannele
dc.contributor.authorVilla, Pia M.
dc.contributor.authorReynolds, Rebecca M.
dc.contributor.authorNystad, Wenche
dc.contributor.authorHaberg, Siri E.
dc.contributor.authorLondon, Stephanie J.
dc.contributor.authorO'Donnell, Kieran J.
dc.contributor.authorGarg, Elika
dc.contributor.authorMeaney, Michael J.
dc.contributor.authorEntringer, Sonja
dc.contributor.authorWadhwa, Pathik D.
dc.contributor.authorBuss, Claudia
dc.contributor.authorJones, Meaghan J.
dc.contributor.authorLin, David T. S.
dc.contributor.authorMacIsaac, Julie L.
dc.contributor.authorKobor, Michael S.
dc.contributor.authorKoen, Nastassja
dc.contributor.authorZar, Heather J.
dc.contributor.authorKoenen, Karestan C.
dc.contributor.authorDalvie, Shareefa
dc.contributor.authorStein, Dan J.
dc.contributor.authorKondofersky, Ivan
dc.contributor.authorMueller, Nikola S.
dc.contributor.authorTheis, Fabian J.
dc.contributor.authorRaikkonen, Katri
dc.contributor.authorBinder, Elisabeth B.
dc.contributor.authorWray, Naomi R.
dc.contributor.authorRipke, Stephan
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorTrzaskowski, Maciej
dc.contributor.authorByrne, Enda M.
dc.contributor.authorAbdellaoui, Abdel
dc.contributor.authorAdams, Mark J.
dc.contributor.authorAgerbo, Esben
dc.contributor.authorAir, Tracy M.
dc.contributor.authorAndlauer, Till F. M.
dc.contributor.authorBacanu, Silviu-Alin
dc.contributor.authorBaekvad-Hansen, Marie
dc.contributor.authorBeekman, Aartjan T. F.
dc.contributor.authorBigdeli, Tim B.
dc.contributor.authorBlackwood, Douglas H. R.
dc.contributor.authorBryois, Julien
dc.contributor.authorButtenschon, Henriette N.
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorCai, Na
dc.contributor.authorCastelao, Enrique
dc.contributor.authorChristensen, Jane Hvarregaard
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorColeman, Jonathan R.
dc.contributor.authorColodro-Conde, Lucia
dc.contributor.authorCouvy-Duchesne, Baptiste
dc.contributor.authorCraddock, Nick
dc.contributor.authorCrawford, Gregory E.
dc.contributor.authorDavies, Gail
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorDerks, Eske M.
dc.contributor.authorDolan, Conor
dc.contributor.authorDunn, Erin C.
dc.contributor.authorEley, Thalia C.
dc.contributor.authorEscott-Price, Valentina
dc.contributor.authorKiadeh, Farnush Farhadi Hassan
dc.contributor.authorFinucane, Hilary K.
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorFrank, Josef
dc.contributor.authorGaspar, Helena A.
dc.contributor.authorGill, Michael
dc.contributor.authorGoes, Fernando S.
dc.contributor.authorGordon, Scott D.
dc.contributor.authorGrove, Jakob
dc.contributor.authorHall, Lynsey S.
dc.contributor.authorHansen, Christine Soholm
dc.contributor.authorHansen, Thomas F.
dc.contributor.authorHerms, Stefan
dc.contributor.authorHickie, Ian B.
dc.contributor.authorHoffmann, Per
dc.contributor.authorHomuth, Georg
dc.contributor.authorHorn, Carsten
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHougaard, David M.
dc.contributor.authorIsing, Marcus
dc.contributor.authorJansen, Rick
dc.contributor.authorJorgenson, Eric
dc.contributor.authorKnowles, James A.
dc.contributor.authorKohane, Isaac S.
dc.contributor.authorKraft, Julia
dc.contributor.authorKretzschmar, Warren W.
dc.contributor.authorKrogh, Jesper
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLi, Yihan
dc.contributor.authorLind, Penelope A.
dc.contributor.authorMacIntyre, Donald J.
dc.contributor.authorMacKinnon, Dean F.
dc.contributor.authorMaier, Robert M.
dc.contributor.authorMaier, Wolfgang
dc.contributor.authorMarchini, Jonathan
dc.contributor.authorMbarek, Hamdi
dc.contributor.authorMcGrath, Patrick
dc.contributor.authorMcGuffin, Peter
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMehta, Divya
dc.contributor.authorMiddeldorp, Christel M.
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMilani, Lili
dc.contributor.authorMondimore, Francis M.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMostafavi, Sara
dc.contributor.authorMullins, Niamh
dc.contributor.authorNauck, Matthias
dc.contributor.authorNg, Bernard
dc.contributor.authorNivard, Michel G.
dc.contributor.authorNyholt, Dale R.
dc.contributor.authorO'Reilly, Paul F.
dc.contributor.authorOskarsson, Hogni
dc.contributor.authorOwen, Michael J.
dc.contributor.authorPainter, Jodie N.
dc.contributor.authorPedersen, Carsten Bocker
dc.contributor.authorPedersen, Marianne Girtz
dc.contributor.authorPeterson, Roseann E.
dc.contributor.authorPettersson, Erik
dc.contributor.authorPeyrot, Wouter J.
dc.contributor.authorPistis, Giorgio
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorQuiroz, Jorge A.
dc.contributor.authorQvist, Per
dc.contributor.authorRice, John P.
dc.contributor.authorRiley, Brien P.
dc.contributor.authorRivera, Margarita
dc.contributor.authorMirza, Saira Saeed
dc.contributor.authorSchoevers, Robert
dc.contributor.authorSchulte, Eva C.
dc.contributor.authorShen, Ling
dc.contributor.authorShi, Jianxin
dc.contributor.authorShyn, Stanley
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorSinnamon, Grant C. B.
dc.contributor.authorSmit, Johannes H.
dc.contributor.authorSmith, Daniel J.
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorStreit, Fabian
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorTansey, Katherine E.
dc.contributor.authorTeismann, Henning
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThompson, Wesley
dc.contributor.authorThomson, Pippa A.
dc.contributor.authorThorgeirsson, Thorgeir E.
dc.contributor.authorTraylor, Matthew
dc.contributor.authorTreutlein, Jens
dc.contributor.authorTrubetskoy, Vassily
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorUmbricht, Daniel
dc.contributor.authorVan der Auwera, Sandra
dc.contributor.authorvan Hemert, Albert M.
dc.contributor.authorViktorin, Alexander
dc.contributor.authorVisscher, Peter M.
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWebb, Bradley T.
dc.contributor.authorWeinsheimer, Shantel Marie
dc.contributor.authorWellmann, Juergen
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorWu, Yang
dc.contributor.authorXi, Hualin S.
dc.contributor.authorYang, Jian
dc.contributor.authorZhang, Futao
dc.contributor.authorArolt, Volker
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorBerger, Klaus
dc.contributor.authorBoomsma, Dorret
dc.contributor.authorCichon, Sven
dc.contributor.authorDannlowski, Udo
dc.contributor.authorde Geus, E. J. C.
dc.contributor.authorDePaulo, J. Raymond
dc.contributor.authorDomenici, Enrico
dc.contributor.authorEsko, Tonu
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorHamilton, Steven P.
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeath, Andrew C.
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorKloiber, Stefan
dc.contributor.authorLewis, Glyn
dc.contributor.authorLi, Qingqin S.
dc.contributor.authorLucae, Susanne
dc.contributor.authorMadden, Pamela A. F.
dc.contributor.authorMagnusson, Patrik K.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben Bo
dc.contributor.authorMueller-Myhsok, Bertram
dc.contributor.authorNordentoft, Merete
dc.contributor.authorNoethen, Markus M.
dc.contributor.authorO'Donovan, Michael C.
dc.date.accessioned2021-03-02T21:25:06Z
dc.date.available2021-03-02T21:25:06Z
dc.identifier.citationCzamara D., Eraslan G., Page C. M. , Lahti J., Lahti-Pulkkinen M., Hamalainen E., Kajantie E., Laivuori H., Villa P. M. , Reynolds R. M. , et al., "Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns", NATURE COMMUNICATIONS, cilt.10, 2019
dc.identifier.issn2041-1723
dc.identifier.otherav_06d126a0-ea33-4d0c-bf64-324fdd016328
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/10432
dc.identifier.urihttps://doi.org/10.1038/s41467-019-10461-0
dc.description.abstractEpigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
dc.language.isoeng
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.subjectTemel Bilimler
dc.subjectMultidisciplinary
dc.titleIntegrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
dc.typeMakale
dc.relation.journalNATURE COMMUNICATIONS
dc.contributor.departmentMax Planck Society , ,
dc.identifier.volume10
dc.contributor.firstauthorID2389352


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