dc.contributor.author | Parman, Yesim | |
dc.contributor.author | Giris, Murat | |
dc.contributor.author | Yetimler, Berrak | |
dc.contributor.author | Tasli, Hatice | |
dc.contributor.author | Tuzun, Erdem | |
dc.contributor.author | Durmus, Hacer | |
dc.date.accessioned | 2021-03-05T08:40:05Z | |
dc.date.available | 2021-03-05T08:40:05Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Giris M., Durmus H., Yetimler B., Tasli H., Parman Y., Tuzun E., "Elevated IL-4 and IFN-γ Levels in Muscle Tissue of Patients with Dermatomyositis.", In vivo (Athens, Greece), cilt.31, ss.657-660, 2017 | |
dc.identifier.issn | 0258-851X | |
dc.identifier.other | av_9a15a2c8-6d4c-4422-a07c-5583f697c84f | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/103603 | |
dc.identifier.uri | https://doi.org/10.21873/invivo.11108 | |
dc.description.abstract | Background/Aim: To investigate the contribution of muscle tissue-derived cytokines in dermatomyositis DM). Materials and Methods: Muscle homogenates were prepared from deltoid muscle biopsy specimens of 10 patients with DM and eight controls with no pathological signs of myopathy. Interleukin IL)-4, interferon IFN)-gamma and IL-17 levels were evaluated by enzyme-linked immunosorbent assay ELISA) and immunoblotting analysis. Muscle strength grades were recorded. Results: Patients with DM showed significantly elevated muscle tissue IL-4 and IFN-gamma levels, whereas IL-17 levels were comparable between patients with DM and controls. Immunoblotting studies confirmed ELISA results. In DM muscle specimens, IL-4 and IFN-gamma levels were positively correlated, while no correlation was observed between IL-17 and the other two cytokines. Moreover, IL-4 and IFN-gamma levels were significantly negative correlated with muscle strength grades for the deltoid muscle. Conclusion: Our results confirm the involvement of T helper Th) 1-type and Th2-type immunity in DM pathogenesis. Muscle tissue appears to contribute to muscle weakness in DM by producing inflammatory cytokines. | |
dc.language.iso | eng | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.title | Elevated IL-4 and IFN-γ Levels in Muscle Tissue of Patients with Dermatomyositis. | |
dc.type | Makale | |
dc.relation.journal | In vivo (Athens, Greece) | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 31 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 657 | |
dc.identifier.endpage | 660 | |
dc.contributor.firstauthorID | 97945 | |