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dc.contributor.authorGorpe, Ugur
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorCalhan, Turan
dc.contributor.authorOzbakir, Fatma
dc.contributor.authorCebeci, Egemen
dc.date.accessioned2021-03-05T08:33:16Z
dc.date.available2021-03-05T08:33:16Z
dc.date.issued2010
dc.identifier.citationCalhan T., Senates E., Cebeci E., Zuhur S. S. , Ozbakir F., Gorpe U., "A comparison of antineutrophil cytoplasmic antibody prevalence in patients treated and untreated for hyperthyroidism", ENDOCRINE, cilt.38, ss.199-205, 2010
dc.identifier.issn1355-008X
dc.identifier.otherav_9978e5c4-7ff7-4f0e-9232-20a14332e7f2
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/103213
dc.identifier.urihttps://doi.org/10.1007/s12020-010-9373-x
dc.description.abstractWe aimed to compare the prevalence of antineutrophil cytoplasmic antibody (ANCA) and its subgroups between on-treatment (with anti-thyroid drugs; propylthiouracil, methimazole) and untreated patients with hyperthyroidism in our unit. Overall 78 consecutive patients were enrolled in the study; 45 patients were on-treatment (female/male 31: 14) and 33 were newly diagnosed (female/male 20: 13). We have studied ANCA, perinuclear-ANCA (p-ANCA), cytoplasmic-ANCA (c-ANCA), myeloperoxidase-ANCA (mpo-ANCA), and proteinase 3-ANCA (pr3-ANCA) in sera of all the patients. The data about clinical status, laboratory tests, and physical examination and mean duration of treatment in treated group were recorded. There was no statistically significant difference between the two groups for ANCA, c-ANCA, and pr3-ANCA (P = 0.13, P = 0.07, and P = 0.63 respectively). p-ANCA and mpo-ANCA prevalences were significantly higher in on-treatment group than in untreated group (P = 0.04 and P = 0.01, respectively). The mean duration of treatment was 17 months in on-treatment group. The use of antithyroid drugs (propylthiouracil, methimazole) seems to be correlated with increased prevalence of ANCA. These drugs may especially increase p-ANCA and mpo-ANCA positivity.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.titleA comparison of antineutrophil cytoplasmic antibody prevalence in patients treated and untreated for hyperthyroidism
dc.typeMakale
dc.relation.journalENDOCRINE
dc.contributor.departmentIstanbul Training & Research Hospital , ,
dc.identifier.volume38
dc.identifier.issue2
dc.identifier.startpage199
dc.identifier.endpage205
dc.contributor.firstauthorID93220


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