dc.contributor.author | Can, Gunay | |
dc.contributor.author | Koldas, Lale | |
dc.contributor.author | Ikitimur, Barış | |
dc.contributor.author | Yıldırım, Erkan | |
dc.contributor.author | Coşansu, Kahraman | |
dc.contributor.author | Cakmak, Huseyin Altug | |
dc.contributor.author | Karadag, Bilgehan | |
dc.date.accessioned | 2021-03-02T21:22:24Z | |
dc.date.available | 2021-03-02T21:22:24Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Coşansu K., Cakmak H. A. , Ikitimur B., Yıldırım E., Can G., Karadag B., Koldas L., "Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: A novel finding", Kardiologia Polska, cilt.72, sa.3, ss.239-245, 2014 | |
dc.identifier.issn | 0022-9032 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_06932da8-08ea-4f77-8e64-36c8fd6e0cee | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/10276 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897136027&origin=inward | |
dc.identifier.uri | https://doi.org/10.5603/kp.a2013.0251 | |
dc.description.abstract | Background: Apelin is a novel endogenous peptide with inotropic and vasodilatory properties. Aim: To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers. Methods: Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes. Results: There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels. Conclusions: Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients. Copyright © Polskie Towarzystwo Kardiologiczne. | |
dc.language.iso | eng | |
dc.subject | CARDIAC ve CARDIOVASCULAR SİSTEMLER | |
dc.subject | Kardiyoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.title | Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: A novel finding | |
dc.type | Makale | |
dc.relation.journal | Kardiologia Polska | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 72 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 239 | |
dc.identifier.endpage | 245 | |
dc.contributor.firstauthorID | 89638 | |