| dc.contributor.author | QI, Huibin | |
| dc.contributor.author | Tuzun, Erdem | |
| dc.contributor.author | CHRISTADOSS, Premkumar | |
| dc.contributor.author | LI, Jing | |
| dc.contributor.author | ALLMAN, Windy | |
| dc.contributor.author | SAINI, Shamsher S. | |
| dc.date.accessioned | 2021-03-05T08:09:56Z | |
| dc.date.available | 2021-03-05T08:09:56Z | |
| dc.identifier.citation | ALLMAN W., QI H., SAINI S. S. , LI J., Tuzun E., CHRISTADOSS P., "CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis", JOURNAL OF NEUROIMMUNOLOGY, cilt.249, ss.1-7, 2012 | |
| dc.identifier.issn | 0165-5728 | |
| dc.identifier.other | av_97788b33-244c-4d79-9a52-bbb04a14fb3b | |
| dc.identifier.other | vv_1032021 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12627/101959 | |
| dc.identifier.uri | https://doi.org/10.1016/j.jneuroim.2012.04.002 | |
| dc.description.abstract | The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle. (C) 2012 Elsevier B.V. All rights reserved. | |
| dc.language.iso | eng | |
| dc.subject | Yaşam Bilimleri (LIFE) | |
| dc.subject | NEUROSCIENCES | |
| dc.subject | Sinirbilim ve Davranış | |
| dc.subject | Yaşam Bilimleri | |
| dc.subject | Temel Bilimler | |
| dc.subject | İmmünoloji | |
| dc.title | CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis | |
| dc.type | Makale | |
| dc.relation.journal | JOURNAL OF NEUROIMMUNOLOGY | |
| dc.contributor.department | University of Texas System , , | |
| dc.identifier.volume | 249 | |
| dc.identifier.startpage | 1 | |
| dc.identifier.endpage | 7 | |
| dc.contributor.firstauthorID | 2345 | |
