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dc.contributor.authorSenocak, Ahmet
dc.contributor.authorSağlık Aslan, Serap
dc.contributor.authorAydoğmuş, Zeynep
dc.contributor.authorYıldız, Gülcemal
dc.date.accessioned2021-03-02T21:20:45Z
dc.date.available2021-03-02T21:20:45Z
dc.identifier.citationAydoğmuş Z., Sağlık Aslan S., Yıldız G., Senocak A., "Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations", JOURNAL OF ANALYTICAL CHEMISTRY, cilt.75, ss.691-700, 2020
dc.identifier.issn1061-9348
dc.identifier.othervv_1032021
dc.identifier.otherav_0662972e-4482-4f52-81ce-ea81c4676c49
dc.identifier.urihttp://hdl.handle.net/20.500.12627/10154
dc.identifier.urihttps://doi.org/10.1134/s1061934820050032
dc.description.abstractElectrochemical properties of regorafenib (REG) were studied in 0.1 M Britton-Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion-adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5-13 mu g/mL and limit of detection was 0.10 mu g/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94%.
dc.language.isoeng
dc.subjectKimya
dc.subjectTemel Bilimler
dc.subjectKİMYA, ANALİTİK
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler (SCI)
dc.titleDifferential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations
dc.typeMakale
dc.relation.journalJOURNAL OF ANALYTICAL CHEMISTRY
dc.contributor.departmentİstanbul Teknik Üniversitesi , Fen-Edebiyat , Kimya
dc.identifier.volume75
dc.identifier.startpage691
dc.identifier.endpage700
dc.contributor.firstauthorID2207908


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