http://hdl.handle.net/20.500.12627/205 Fri, 01 May 2026 01:01:58 GMT 2026-05-01T01:01:58Z http://hdl.handle.net/20.500.12627/1092 On-line multidimensional SPE-LC-(UV)-MS/MS as an alternative approach for analyzing small molecules in biological fluids Çağlar Andaç, Sena; Boos, Karl Siegfried Tue, 01 Jan 2013 00:00:00 GMT http://hdl.handle.net/20.500.12627/1092 2013-01-01T00:00:00Z http://hdl.handle.net/20.500.12627/1093 Online Heart-Cutting Liquid Chromatographic Analysis Of Linezolid In Human Serum Önal, Armağan; Sağırlı, Ahmet Olcay; Demırcı, Seda Sun, 01 Jan 2017 00:00:00 GMT http://hdl.handle.net/20.500.12627/1093 2017-01-01T00:00:00Z http://hdl.handle.net/20.500.12627/1091 Post-antibiotic Effect of Various Antibiotics against Achromobacter xylosoxidans Strains Isolated from Patients with Cystic Fibrosis Nørskov-Lauritsen, Niels; Damar Çelik, Damla; Özbek Çelik, Berna is an emerging pathogen in cystic fibrosis (CF) disease, although relatively limited is known about its clinical impact and optimal management. Pharmacodynamics such as post-antibiotic effect (PAE) are increasingly being applied to the design of antibiotic dosing regimens. In the present study, meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were tested for their PAE.Materials and Methods: The in vitro activities of meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were determined by the microbroth dilution technique. To determine the PAEs, A. xylosoxidans strains in the logarithmic phase of growth were exposed for 1 h to antibiotics. Recovery periods of test cultures were evaluated using viable counting after centrifugation.Results: The mean values of in vitro PAEs at 1xMIC and 4xMIC concentrations were 3.21 ± 0.66 and 3.58 ± 0.68 hours for colistin, 1.54 ± 0.46 and 2.27 ± 0.41 hours for levofloxacin, 2.34 ± 0.48 and 3.47 ± 0.64 hours for tobramycin, 1.72 ± 0.47 and 2.24 ± 0.41 hours for tigecycline 1.91 ± 0.14 and 2.13 ± 0.13 hours for chloramphenicol, respectively. The carbapenem antibiotics exhibited weak PAEs, as expected.Conclusions: This study’s findings could have important implications for the timing of doses during antimicrobial therapy with tested antibiotics. Wed, 01 Jan 2020 00:00:00 GMT http://hdl.handle.net/20.500.12627/1091 2020-01-01T00:00:00Z http://hdl.handle.net/20.500.12627/1087 Taraxacum farinosum Hausskn. & Bornm. bitkisinin antioksidan aktivite yönünden incelenmesi Özsoy, Nurten; Sarı, Aynur; Karahüseyin, Seçil Taraxacum Wigg. cinsi Asteraceae familyasının bir üyesidir. Bu cins Türkiye’de yaklaşık 49 tür ile temsil edilmektedir. Taraxacum türleri halk arasında diüretik olarak, dispepsi, reflü, dalak ve karaciğer rahatsızlıkları, anoreksiya gibi çeşitli hastalıkların tedavisinde kullanılır. Taraxacum türlerinden seskiterpen laktonlar, triterpenler, fitosteroller, flavonoitler, lignanlar, kumarinler, fenolik asitler, beta-karbolin alkaloitleri, indol alkaloitleri, karotenoidler grubundan bileşikler elde edildiği rapor edilmiştir. Bu çalışmada Türkiye için endemik bir tür olan Taraxacum farinosum Hausskn. & Bornm. bitkisinin kök ve toprak üstü kısımlarından elde edilen metanol ekstrelerinin etil asetat ve kloroform fraksiyonları total fenolik bileşik miktarları ve antioksidan potansiyelleri bakımından incelenmiştir. En yüksek total fenolik bileşik miktarı ve antioksidan aktivitenin etil asetat fraksiyonlarında olduğu saptanmıştır.  Wed, 01 Jan 2020 00:00:00 GMT http://hdl.handle.net/20.500.12627/1087 2020-01-01T00:00:00Z