http://hdl.handle.net/20.500.12627/214 2026-05-01T03:31:54Z http://hdl.handle.net/20.500.12627/1091 Post-antibiotic Effect of Various Antibiotics against Achromobacter xylosoxidans Strains Isolated from Patients with Cystic Fibrosis Nørskov-Lauritsen, Niels; Damar Çelik, Damla; Özbek Çelik, Berna is an emerging pathogen in cystic fibrosis (CF) disease, although relatively limited is known about its clinical impact and optimal management. Pharmacodynamics such as post-antibiotic effect (PAE) are increasingly being applied to the design of antibiotic dosing regimens. In the present study, meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were tested for their PAE.Materials and Methods: The in vitro activities of meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were determined by the microbroth dilution technique. To determine the PAEs, A. xylosoxidans strains in the logarithmic phase of growth were exposed for 1 h to antibiotics. Recovery periods of test cultures were evaluated using viable counting after centrifugation.Results: The mean values of in vitro PAEs at 1xMIC and 4xMIC concentrations were 3.21 ± 0.66 and 3.58 ± 0.68 hours for colistin, 1.54 ± 0.46 and 2.27 ± 0.41 hours for levofloxacin, 2.34 ± 0.48 and 3.47 ± 0.64 hours for tobramycin, 1.72 ± 0.47 and 2.24 ± 0.41 hours for tigecycline 1.91 ± 0.14 and 2.13 ± 0.13 hours for chloramphenicol, respectively. The carbapenem antibiotics exhibited weak PAEs, as expected.Conclusions: This study’s findings could have important implications for the timing of doses during antimicrobial therapy with tested antibiotics. 2020-01-01T00:00:00Z http://hdl.handle.net/20.500.12627/1087 Taraxacum farinosum Hausskn. & Bornm. bitkisinin antioksidan aktivite yönünden incelenmesi Özsoy, Nurten; Sarı, Aynur; Karahüseyin, Seçil Taraxacum Wigg. cinsi Asteraceae familyasının bir üyesidir. Bu cins Türkiye’de yaklaşık 49 tür ile temsil edilmektedir. Taraxacum türleri halk arasında diüretik olarak, dispepsi, reflü, dalak ve karaciğer rahatsızlıkları, anoreksiya gibi çeşitli hastalıkların tedavisinde kullanılır. Taraxacum türlerinden seskiterpen laktonlar, triterpenler, fitosteroller, flavonoitler, lignanlar, kumarinler, fenolik asitler, beta-karbolin alkaloitleri, indol alkaloitleri, karotenoidler grubundan bileşikler elde edildiği rapor edilmiştir. Bu çalışmada Türkiye için endemik bir tür olan Taraxacum farinosum Hausskn. & Bornm. bitkisinin kök ve toprak üstü kısımlarından elde edilen metanol ekstrelerinin etil asetat ve kloroform fraksiyonları total fenolik bileşik miktarları ve antioksidan potansiyelleri bakımından incelenmiştir. En yüksek total fenolik bileşik miktarı ve antioksidan aktivitenin etil asetat fraksiyonlarında olduğu saptanmıştır.  2020-01-01T00:00:00Z http://hdl.handle.net/20.500.12627/1089 EVALUATION OF ANTIMICROBIAL AND CYTOTOXIC EFFECTS OF FOUR TURKISH SPECIES OF ERYNGIUM L. Mataracı Kara, Emel; Ecevit Genç, Gülay; Genç, İlker; Melikoğlu, Gülay; Bozkurt Güzel, Çağla; Kurtoğlu Anıl, Sezin; Özbek Çelik, Berna 2019-01-01T00:00:00Z http://hdl.handle.net/20.500.12627/1088 Cognitive Evaluation of Bupropion Sustained Release in Heavy Tobacco Smokers Using Event-Related Potentials Ozdemir, Osman; Erdem, Ozge; Demiralp, Tamer; Cuhadaroglu, Caglar; Ergen, Mehmet; Uslu, Atilla Objective. The aim of this study was to investigate the effects of bupropion sustained release (SR) on cognitive function, evaluated by event-related potentials (ERPs), in heavy tobacco smokers. 2012-01-01T00:00:00Z