dc.contributor.author | Bakkaloglu, H. | |
dc.contributor.author | Turkmen, A. | |
dc.contributor.author | Guney, I. | |
dc.contributor.author | Nane, I. | |
dc.contributor.author | Aydın, Ali Fuat | |
dc.contributor.author | Gurtekin, M. | |
dc.contributor.author | Ciftci, H. S. | |
dc.contributor.author | Ayna, T. K. | |
dc.contributor.author | Caliskan, Y. K. | |
dc.date.accessioned | 2021-03-03T09:57:21Z | |
dc.date.available | 2021-03-03T09:57:21Z | |
dc.identifier.citation | Ciftci H. S. , Ayna T. K. , Caliskan Y. K. , Guney I., Bakkaloglu H., Nane I., Aydın A. F. , Turkmen A., Gurtekin M., "Effect of MDR1 Polymorphisms on the Blood Concentrations of Tacrolimus in Turkish Renal Transplant Patients", TRANSPLANTATION PROCEEDINGS, cilt.45, ss.895-900, 2013 | |
dc.identifier.issn | 0041-1345 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_1fd2a826-93e6-4d2a-b76a-e2d836c04d06 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/26488 | |
dc.identifier.uri | https://doi.org/10.1016/j.transproceed.2013.02.055 | |
dc.description.abstract | Background. Tacrolimus, a calcineurin inhibitor, is prescribed to prevent allograft rejection in renal transplantation. Tacrolimus not only has a narrow therapeutic index, but also shows significant interindividual differences. The absorption and metabolism of this drug are affected by multidrug resistance (MDR) 1 gene polymorphisms that correlated with single-nucleotide polymorphisms (SNPs) affecting in vivo P-glycoprotein activity. This study investigated associations of MDR1 gene C3435T polymorphism with tacrolimus blood concentrations and dose requirements as well as acute rejection episodes among Turkish renal transplant patients. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | TRANSPLANTASYON | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | CERRAHİ | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | İmmünoloji | |
dc.title | Effect of MDR1 Polymorphisms on the Blood Concentrations of Tacrolimus in Turkish Renal Transplant Patients | |
dc.type | Makale | |
dc.relation.journal | TRANSPLANTATION PROCEEDINGS | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 45 | |
dc.identifier.startpage | 895 | |
dc.identifier.endpage | 900 | |
dc.contributor.firstauthorID | 2484463 | |