Moving Dipoles Method Detects Displacement in N2 and P3 Generation in Diffuse Axonal Injury Patients

Abstract

Physiological neural mechanisms underlying attentional processes were investigated by means of moving dipoles method in survivors of diffuse axonal injury (DAI) and in a control group. N2 and P3 components were obtained by means of the administration of the Conner's Continuous Performance Test. Analysis of behavioral responses showed significant between- group differences in reaction times and error rates. A different number of dipoles was needed for the reconstruction of both N2 and P3 components in the two groups. The study of dipoles location revealed major displacements in damaged brains with respect to physiology. In conclusion, data from DAI patients showed that neuronal reorganization following brain injury evolves towards the generation of multiple central sources.