Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu

Assessment of global and gene-specific DNA methylation in rat liver and kidney in response to non-genotoxic carcinogen exposure

Ozden, Sibel; Mally, Angela; Kara, Neslihan Turgut; Chen, Tao; Alpertunga, Buket; Chipman, J. Kevin; Durasi, Ilknur Melis; Sezerman, Osman Uğur; Demirel, Goksun (2015)

Altered expression of tumor suppressor genes and oncogenes, which is regulated in part at the level of DNA methylation, is an important event involved in non-genotoxic carcinogenesis. This may serve as a marker for early ...
Effects of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites on DNA damage and repair under in vitro conditions

Ozcagli, Eren; Alpertunga, Buket; Tsatsakis, Aristidis M.; Fenga, Concettina; Tsıtsımpıkou, Christina; Wilks, Martin F.; Berktas, Mehmet (2016)

3-monochloropropane-1,2-diol (3-MCPD) is a food contaminant that occurs during industrial production processes and can be found mainly in fat and salt containing products. 3-MCPD has exhibited mutagenic activity in vitro ...
DNA methylation analysis in rat kidney epithelial cells exposed to 3-MCPD and glycidol

Ozden, Sibel; Senyildiz, Mine; Alpertunga, Büket (2017)

3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food processing contaminant that has been regarded as a rat carcinogen, which is known to induce Leydig-cell and mammary gland tumors in males, as well as kidney tumors ...