DETERMINATION OF TROPICAMIDE ABUSE IN HAIR WITH A VALIDATED GC-MS METHOD

Abstract

Objective: Tropicamide is an antimuscarinic drug used topically by clinicians prior to eye examination for its cycloplegic and mydriatic effects. It is included in the controlled drug-list since the second half of 2012 in Turkey due to abuse potential. There is no literature concerning the determination of tropicamide from hair sample. In this study, tropicamide determination method was validated partially by GC-MS and applied on an abuser's hair sample.