Ghrelin levels are decreased in non-obese prepubertal children born large for gestational age

Abstract

Background: Ghrelin is the natural ligand of GH secretagogue receptor. It has several metabolic functions including regulation of food intake, energy homeostasis, and body weight. An inverse relationship between fasting plasma ghrelin and insulin concentrations has been shown. Being born large for gestational age (LGA) has all increased risk of developing insulin resistance.