MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study.
Yazar
Antozzi, C.
Evoli, A.
Brenner, T.
Vaknin, A.
Berrih-Aknin, S.
Behin, A.
Sharshar, T.
De Baets, M.
Losen, M.
Martinez-Martinez, P.
Kleopa, K. A.
Zamba-Papanicolaou, E.
Kyriakides, T.
Kostera-Pruszczyk, A.
Szczudlik, P.
Szyluk, B.
Lavrnic, D.
Basta, I.
Peric, S.
Tallaksen, C.
Maniaol, A.
Pons, C. Casasnovas
Pitha, J.
Jakubikova, M.
Hanisch, F.
Tzartos, S. J.
Deymeer, F.
Saruhan-Direskeneli, G.
Durmus, Hacer
Tsonis, A. I.
Zisimopoulou, P.
Lazaridis, K.
Tzartos, J.
Matsigkou, E.
Zouvelou, V.
Mantegazza, R.
Andreetta, F.
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Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed. (C) 2015 Elsevier B.V. All rights reserved.
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