Synthesis and anticonvulsant activity of new 3-[(2-furyl)carbonyl] amino-4-thiazolidinone and 2-[(2-furyl)carbonyl]hydrazono-4-thiazoline derivatives

Abstract

A series of new 2-aryl-3-[(2-furyl)carbonyl]amino-5-nonsubstituted/methyl-4-thiazolidinones (3) and 2-[(2-furyl)carbonyl]hydrazono-3-alkyl-4-thiazolines (5) was synthesized and evaluated for anticonvulsant activity against pentylenetetrazole induced seizures. Preliminary results indicated that potency was sensitive to substituents at the 2 and 5 positions of the 4-thiazolidinone and 3 and 4 positions of the 4-thiazoline rings. Among 3, 2-(phenyl)/(4-fluorophenyl)-3-[(2-furyl)carbonyl]amino-5-methyl-4-thiazolidiones (3e and 3f) and among 5,2-[(2-furyl)carbonyl]hydrazono-3-allyl-4-(4-bromophenyl)-4-thiazoline (5e), showed the highest protection (40%).