Effect and Safety of Granulocyte Transfusions in Pediatric Patients With Febrile Neutropenia or Defective Granulocyte Functions

Abstract

Background: Despite the introduction of new broad-spectrum antibiotics and antifungal therapies over the past decade, infections remains the most frequent cause of death in patients with neutropenia. The aim of this study is to assess the effect and safety of granulocyte transfusions (GTX) for the treatment of severe life-threatening infections in pediatric patients with febrile neutropenia or defective granulocyte functions.