Volumetry of the Thalamus in Idiopathic Generalized Epilepsy

Abstract

Objective: Studies aiming to explain the pathophysiology of idiopathic generalized epilepsy (IGE) indicate that the epileptic activity arises from thalamocortical circuitry. The aims of this study were to explore the pathophysiology of IGE using the thalamic volume measurements and to compare the measurement results between subsyndromes of IGE, between different seizure types and between the presence/absence of absence status epilepticus and, finally, to evaluate the effect of the possible differences on pathogenetic mechanisms of IGE.