Propylthiouracil-Induced Thrombotic Leukocytoclastic Vasculitis

Abstract

Antithyroid drug therapy with Propylthiouracil (PTU) is commonly used in Graves' disease. One of the most serious complications of this drug is PTU-induced leukocytoclastic vasculitis. We report a 23 year-old woman who developed leukocytoclastic vasculitis which is a rare and serious side effect during PTU therapy for Graves' disease. The observation of cutaneous vasculitis in this patient during administration of PTU indicates that reguler follow-up of patients on antithyroid drug regimen is mandatory.