Visual Morbidity in Ocular Tuberculosis - Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6
Yazar
Chee, Soon-Phaik
Invernizzi, Alessandro
Goldstein, Debra A.
Herbort, Carl P.
Barisani-Asenbauer, Talin
Gonzalez-Lopez, Julio J.
Androudi, Sofia
Bansal, Reema
Moharana, Bruttendu
Degli Esposti, Simona
Tasiopoulou, Anastasia
Nadarajah, Sengal
Agarwal, Mamta
Abraham, Sharanaya
Vala, Ruchi
Singh, Ramandeep
Sharma, Aman
Sharma, Kusum
Zierhut, Manfred
Kon, Onn Min
Cunningham, Emmett T.
Kempen, John H.
Quan Dong Nguyen, Quan Dong Nguyen
Pavesio, Carlos
Gupta, Vishali
Cimino, Luca
Narain, Shishir
Biswas, Jyotirmay
Agrawal, Rupesh
Gunasekeran, Dinesh Visva
Agarwal, Aniruddha
Testi, Ilaria
Carreno, Ester
Westcott, Mark
Mahajan, Sarakshi
Raje, Dhananjay
Aggarwal, Kanika
Murthy, Somasheila
Mccluskey, Peter
Ho, Su Ling
Teoh, Stephen
Agarwal, Manisha
Mahendradas, Padmamalini
Khairallah, Moncef
Jones, Nicholas
Tugal-Tutkun, Ilknur
Babu, Kalpana
Basu, Soumayava
Lee, Richard
Al-Dhibi, Hassan
Bodaghi, Bahram
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Objective Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods Multi-center retrospective cohort study. Main outcomes were VI. Results A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p< .001). Mean BCVA was worse at 12-18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.
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