Predictors of treatment requirement in HBeAg-negative chronic hepatitis B patients with persistently normal alanine aminotransferase and high serum HBV DNA levels

Yazar
Pinarbasi, Binnur
Badur, Selim
Kaymakoglu, Sabahattin
Demir, Kadir
Besisik, Fatih
Gulluoglu, Mine
Sumnu, Abdullah
Akyuz, Filiz
Baran, Bulent
Gokturk, Suut
Karaca, Cetin
Ormeci, Asli
Aydın, Yücel
Soyer, Ozlem Mutluay
Onel, Derya
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Özet
Objectives: Serum alanine aminotransferase (ALT) is a controversial marker for disease monitoring in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. The aim of this study was to determine the fibrosis stage and histological activity index (HAI) in HBeAg-negative CHB patients with persistently normal ALT (PNALT) and high serum HBV DNA (>= 2000 IU/ml) and to investigate clinical risk factors for the requirement of treatment through the examination of liver biopsy specimens.
Bağlantı
http://hdl.handle.net/20.500.12627/47929
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84993978170&origin=inward
https://doi.org/10.1016/j.ijid.2016.09.007
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