Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

Date
2008
Author
Yamanaka, Noboru
Palanduz, Sukru
Fukushima, Kunihiro
Shimizu, Kenji
Ozturk, Sukru
Pehlivan, Davut
Gunduz, Esra
Gunduz, Mehmet
Nagatsuka, Hitoshi
Beder, Levent Bekir
Cengiz, Beyhan
Rivera, Rosario S.
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Abstract
Purpose and methods Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.
URI
http://hdl.handle.net/20.500.12627/47406
https://doi.org/10.1007/s00432-008-0423-1
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