TNF-alpha 863C > A promoter and TNFRII 196T > G exonic variations may be risk factors for juvenile idiopathic arthritis

Abstract

Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients.