Effects of Leptin, Resistin, and PPAR-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population

Abstract

Objective: Obesity and acute coronary syndrome (ACS) are common health problems of recent years. There are many candidate genes related to thegenetic infrastructure of ACS and obesity. This study aimed to investigate the association of Leptin glutamine to arginine substitution (Gln223Arg),Resistin-420 Cytosine/Guanine (C/G), and proliferator-activated receptor-gamma (PPAR-γ) proline to alanine substitution (Pro12Ala) polymorphismsin obese patients with ACS in the Turkish population.Methods: Fifty obese patients concurrently diagnosed with ACS and 42 healthy controls were included in this study. These polymorphisms wereanalyzed using the polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis methods.Results: The PPAR-γ Pro12Ala polymorphism Pro/Ala genotype (p=0.001) was found to be higher in the obese patients with ACS, while the (Proline/Proline) genotype (p=0.001) was significantly higher in the control group. The GC genotype (p=0.045) distribution of Resistin-420 C/G was found tobe significantly higher in the controls compared to the patient group.Conclusion: Our study presents new findings that the PPAR-γ Pro12Ala polymorphism Pro/Ala genotype is a risk factor for ACS in obese individuals,whereas Resistin-420 C/G polymorphism GC genotype and PPAR-γ Pro12Ala polymorphism Pro/Pro genotype may be protective factors for ACS inobese individuals.