The effect of macroprolactinemia on gonadotropin secretion

Abstract

Objectives: Hyperprolactinemia due to monomeric prolactin (m-PRL), is associated with suppression of gonadotropin secretion and gonadal activity. Macroprolactin is thought to be a biologically inactive form of prolactin that has no effects on gonadotropin secretion. We compared follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels in women with macroprolactinemia and in female patients with hyperprolactinemia due to m-PRL.