TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma

Abstract

In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS. as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group were respectively 7.11 +/- 3.3 mug/mg protein, 1.81 +/- 0.39 nmol/mg protein, and 4.29 +/- 3.2 mumol/mg protein, versus 14.45 +/- 4.11 mug/mg protein, 2.14 +/- 0.66 nmol/mg protein, and 2.3 +/- 0.6 mumol/mg protein for normal bladder tissues. Thus, tissue reduced glutathione levels (GSH) were significantly lower in patients as compared with the control group (p 0.05).