Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk

Abstract

Colorectal cancer (CRC) is the third most common cause of cancer-related mortality and causes almost a million deaths worldwide each year. Genetic and environmental factors have gained importance in CRC as well as other types of cancer due to contribution to development of malignancies. Phosholipase C-epsilon 1 PLCE1 is one of the phospholipase family of enzymes and controls cellular responses leading to cell growth, differentiation and gene expression. Therefore, it was evaluated the effects of PLCE1 variations on developing CRC. Rs2274223 was significantly associated with CRC risk (OR = 2.018) while rs3765524 did not significantly differ (p > 0.05). The findings are the first results of PLCE1 profiles in the Turkish and could provide an understanding of aetiology in CRC.