A tungsten supplemented diet attenuates bacterial translocation in chronic portal hypertensive and cholestatic rats: role of xanthine dehydrogenase and xanthine oxidase

Abstract

Background-Bacterial translocation (BT) plays a major role in the pathophysiological process of spontaneous infections in portal hypertension (PII) and cholestatic jaundice. The major mechanisms promoting BT in experimental animal models: are the disruption of the intestinal ecological equilibrium and disruption of the intestinal mucosal barrier. The enzymes xanthine dehydrogenase (XD) and xanthine oxidase (XO) are often implicated as a significant source of oxidants which have a major impact on the impairment of intestinal barrier function.